A zinc metalloproteinase is responsible for the release of CD30 on human tumor cell lines.

@article{Hansen1995AZM,
  title={A zinc metalloproteinase is responsible for the release of CD30 on human tumor cell lines.},
  author={Hinrich Peter Hansen and Tatiana Kisseleva and J{\"o}rg Kobarg and O Horn-Lohrens and B. H. Havsteen and H. Michael Lemke},
  journal={International journal of cancer},
  year={1995},
  volume={63 5},
  pages={750-6}
}
The activation marker CD30 is expressed on the cell surface of the malignant cells in Hodgkin's disease and a few non-Hodgkin lymphomas. We have analyzed the regulation of membrane-bound CD30 and found that the binding of a variety of anti-CD30 antibodies induced down-regulation of CD30 on cell lines. In addition, such down-modulation was also observed after treatment of the cell surface proteins with the sulfhydryl reagent iodoacetamide or after stimulation of the second messenger pathway with… CONTINUE READING

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