A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12

@inproceedings{Burger2014AZM,
  title={A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12},
  author={Alexa Burger and A. I. Vasilyev and Ritu Tomar and Martin Karl Selig and G. Petur Nielsen and Randall T. Peterson and Iain A Drummond and Daniel A. Haber},
  booktitle={Disease models & mechanisms},
  year={2014}
}
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord, with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment, usually in combination with radiation therapy, but neither chemotherapeutic nor targeted therapeutic approaches have demonstrated success. No animal model and only few chordoma cell lines are available for preclinical drug testing, and, although no druggable genetic drivers have been identified, activation of… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord , with its origin in the bones of the axial skeleton .
The mTORC1 inhibitor rapamycin , which has some demonstrated activity in a chordoma cell line , delays the onset of tumor formation in our zebrafish model , and improves survival of tumor - bearing fish .
The mTORC1 inhibitor rapamycin , which has some demonstrated activity in a chordoma cell line , delays the onset of tumor formation in our zebrafish model , and improves survival of tumor - bearing fish .
Consequently , the HRASV12-driven zebrafish model of chordoma could enable high - throughput screening of potential therapeutic agents for the treatment of this refractory cancer .
The zebrafish tumors share characteristics of human chordoma as demonstrated by immunohistochemistry and electron microscopy .
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord , with its origin in the bones of the axial skeleton .
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord , with its origin in the bones of the axial skeleton .
Skeletal boneIs primary anatomic site of diseaseChordoma
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord , with its origin in the bones of the axial skeleton .
Skeletal boneIs associated anatomic site ofChordoma
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord , with its origin in the bones of the axial skeleton .
All Topics