A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

@article{Kaufman2016AZM,
  title={A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation},
  author={Charles K Kaufman and Christian Mosimann and Zi Peng Fan and Song Yang and Andrew Jeffrey Thomas and Julien Ablain and Justin Tan and Rachel D. Fogley and E. Nico van Rooijen and Elliott Jennings Hagedorn and Christie Ciarlo and Richard M White and Dominick A. Matos and Ann-Christin Puller and Cristina Santoriello and Eric C. Liao and Richard A Young and Leonard I. Zon},
  journal={Science},
  year={2016},
  volume={351}
}
The “cancerized field” concept posits that cancer-prone cells in a given tissue share an oncogenic mutation, but only discreet clones within the field initiate tumors. Most benign nevi carry oncogenic BRAFV600E mutations but rarely become melanoma. The zebrafish crestin gene is expressed embryonically in neural crest progenitors (NCPs) and specifically reexpressed in melanoma. Live imaging of transgenic zebrafish crestin reporters shows that within a cancerized field (BRAFV600E-mutant; p53… CONTINUE READING
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