A yeast protein with homology to the beta-subunit of G proteins is involved in control of heme-regulated and catabolite-repressed genes.

@article{Zhang1991AYP,
  title={A yeast protein with homology to the beta-subunit of G proteins is involved in control of heme-regulated and catabolite-repressed genes.},
  author={Min Zhang and Lynne Rosenblum-Vos and Charles V Lowry and Kwame A. Boakye and Richard S. Zitomer},
  journal={Gene},
  year={1991},
  volume={97 2},
  pages={153-61}
}
The product of the Saccharomyces cerevisiae AER2 gene is responsible for maintaining repression of at least two distinct regulatory pathways: heme activation/repression and catabolite repression. Mutations in the gene caused an eightfold increase in the expression of the heme-activated CYC1 gene in the absence of heme, a substantial increase in the expression of the heme-repressed ANB1 gene in the presence of heme, and a 13-fold increase in the expression of the catabolite-repressed GAL1 gene… CONTINUE READING
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