A yeast origin of replication is activated late in S phase.

  title={A yeast origin of replication is activated late in S phase.},
  author={B M Ferguson and Bonita J. Brewer and A Estes Reynolds and Walton L. Fangman},
  volume={65 3},
The mechanism that causes large regions of eukaryotic chromosomes to remain unreplicated until late in S phase is not understood. We have found that 67 kb of telomere-adjacent DNA at the right end of chromosome V in S. cerevisiae is replicated late in S phase. An ARS element in this region, ARS501, was shown by two-dimensional gel analysis to be an active origin of replication. Kinetic analyses indicate that the rate of replication fork movement within this late region is similar to that in… CONTINUE READING

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