A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

@article{Supek1996AYM,
  title={A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.},
  author={Frantisek Supek and Lubica Supekov{\'a} and H. Roice Nelson and Nathan Alfred Nelson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 10},
  pages={5105-10}
}
A novel Saccharomyces cerevisiae mutant, unable to grow in the presence of 12.5 mM EGTA, was isolated by replica plating. The phenotype of the mutant is caused by a single amino acid change (Gly149 to Arg) in the essential yeast gene CDC1. The mutant could be suppressed by overexpression of the SMF1 gene, which was isolated as an extragenic high-copy suppressor. The SMF1 gene codes for a highly hydrophobic protein and its deletion renders the yeast cells sensitive to low manganese concentration… CONTINUE READING
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