A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells.

@article{Santos2014AXB,
  title={A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells.},
  author={Francisco F dos Santos and Andrew M Campbell and Ana Fernandes-Platzgummer and Pedro Z. Andrade and Jeffrey M. Gimble and Yuan Wen and Shayne Boucher and Mohan C. Vemuri and Cl{\'a}udia L da Silva and Joaquim M S Cabral},
  journal={Biotechnology and bioengineering},
  year={2014},
  volume={111 6},
  pages={1116-27}
}
The large cell doses (>1 × 10(6)  cells/kg) used in clinical trials with mesenchymal stem/stromal cells (MSC) will require an efficient production process. Moreover, monitoring and control of MSC ex-vivo expansion is critical to provide a safe and reliable cell product. Bioprocess engineering approaches, such as bioreactor technology, offer the adequate tools to develop and optimize a cost-effective culture system for the rapid expansion of human MSC for cellular therapy. Herein, a xenogeneic… CONTINUE READING
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