A x C rat prostate adenocarcinoma: initial characterization of testosterone regulation of hormone receptors of cultured cancer cells and derived tumors.

@article{Shain1981AXC,
  title={A x C rat prostate adenocarcinoma: initial characterization of testosterone regulation of hormone receptors of cultured cancer cells and derived tumors.},
  author={Sydney A. Shain and Robert W. Boesel and S. S. Kalter and Richard L. Heberling},
  journal={Journal of the National Cancer Institute},
  year={1981},
  volume={66 3},
  pages={565-74}
}
A x C rat prostate cancer cells were established in continuous culture. The polygonal epithelial cells had granular cytoplasm and well-defined cell margins, contained round to oval nuclei with prominent nucleoli, and were tumorigenic when inoculated into A x C male rats. The tumors produced by the injected prostate cancer cells grew as well-vascularized, solid, cribriform adenocarcinomas. The rat prostate cancer cells and derived tumors contained cytoplasmic and nuclear androgen receptors and… CONTINUE READING