A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis

@article{Pollier2018AWA,
  title={A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis},
  author={Jacob Pollier and Emmelien Vancaester and Unnikrishnan Kuzhiumparambil and Claudia E. Vickers and Klaas Vandepoele and Alain Goossens and Michele Fabris},
  journal={Nature Microbiology},
  year={2018},
  volume={4},
  pages={226-233}
}
Steroids are essential triterpenoid molecules that are present in all eukaryotes and modulate the fluidity and flexibility of cell membranes. Steroids also serve as signalling molecules that are crucial for growth, development and differentiation of multicellular organisms1–3. The steroid biosynthetic pathway is highly conserved and is key in eukaryote evolution4–7. The flavoprotein squalene epoxidase (SQE) catalyses the first oxygenation reaction in this pathway and is rate limiting. However… 
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