A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals.

@article{Franco2008AWR,
  title={A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals.},
  author={Sandra Franco and Bonaventura Clotet and Miguel {\'A}ngel Mart{\'i}nez},
  journal={Virus research},
  year={2008},
  volume={131 2},
  pages={260-70}
}
The hepatitis C virus (HCV) NS3/4A protease acts as an antagonist of virus-induced interferon (IFN) regulatory factor (IRF)-3 activation and IFN-beta expression. The NS3/4A protease performs this function by cleaving Cardif and TRIF proteins to block retinoic-acid-inducible gen I (RIG-I) and toll-like receptor (TLR)-3 signaling, respectively. NS3/4A protease inhibition can prevent Cardif and/or TRIF inactivation during HCV infection, thereby maintaining the innate immune response. Thus… CONTINUE READING
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