A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosis.

@article{Deng2002AWL,
  title={A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosis.},
  author={H. W. Deng and Fu-Hua Xu and Q. Huang and Hui Shen and Hongyi Deng and Theresa M. Conway and Yong-Jun Liu and Yao-zhong Liu and Jin-Long Li and Hai-Tao Zhang and K. Michael Davies and Robert Roy Recker},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 11},
  pages={5151-9}
}
Osteoporosis is an important health problem, particularly in the elderly women. Bone mineral density (BMD) is a major determinant of osteoporosis. For a sample of 53 pedigrees that contain 1249 sibling pairs, 1098 grandparent-grandchildren pairs, and 2589 first cousin pairs, we performed a whole- genome linkage scan using 380 microsatellite markers to identify genomic regions that may contain quantitative trait loci (QTL) of BMD. Each pedigree was ascertained through a proband with BMD values… CONTINUE READING

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