A whole-genome association study of major determinants for host control of HIV-1.

  title={A whole-genome association study of major determinants for host control of HIV-1.},
  author={Jacques Fellay and Kevin V. Shianna and Dongliang Ge and Sara Colombo and Bruno Ledergerber and Mike E Weale and Kunlin Zhang and Curtis Gumbs and Antonella Castagna and Andrea Cossarizza and A. Cozzi-lepri and Andrea De Luca and Philippa Jane Easterbrook and Patrick B. Francioli and Simon A Mallal and Javier Martinez-Picado and Jose M Mir{\'o} and Niels Obel and Jason P. Smith and Josiane Wyniger and Patrick Descombes and Stylianos E. Antonarakis and Norman L. Letvin and Andrew J McMichael and Barton F. Haynes and Amalio Telenti and D. B. Goldstein},
  volume={317 5840},
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte… CONTINUE READING
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Immunity 1999;10:661

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Immunogenetics 1993;38:47

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