A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients

@article{Tohkin2013AWA,
  title={A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients},
  author={Masahiro Tohkin and Nahoko Kaniwa and Yoshiro Saito and Emiko Sugiyama and Kouichi Kurose and Jun Nishikawa and Ryuichi Hasegawa and Michiko Aihara and Kayoko Matsunaga and Masamichi Abe and Hirokazu Furuya and Yoko Takahashi and Hiroko Kurimasa Ikeda and Masaaki Muramatsu and M Ueta and Chie Sotozono and Shigeru Kinoshita and Zenro Ikezawa},
  journal={The Pharmacogenomics Journal},
  year={2013},
  volume={13},
  pages={60-69}
}
Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe, cutaneous adverse drug reactions that are rare but life threatening. Genetic biomarkers for allopurinol-related SJS/TEN in Japanese were examined in a genome-wide association study in which Japanese patients (n=14) were compared with ethnically matched healthy controls (n=991). Associations between 890 321 single nucleotide polymorphisms and allopurinol-related SJS/TEN were analyzed by the Fisher's exact test… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
48 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…