A whole blood immunoassay using gold nanoshells.

@article{Hirsch2003AWB,
  title={A whole blood immunoassay using gold nanoshells.},
  author={Lee R Hirsch and Joseph B. Jackson and Andrew Lee and Naomi J. Halas and Jennifer L West},
  journal={Analytical chemistry},
  year={2003},
  volume={75 10},
  pages={2377-81}
}
A rapid immunoassay capable of detecting analyte within complex biological media without any sample preparation is described. This was accomplished using gold nanoshells, layered dielectric-metal nanoparticles whose optical resonance is a function of the relative size of its constituent layers. Aggregation of antibody/nanoshell conjugates with extinction spectra in the near-infrared was monitored spectroscopically in the presence of analyte. Successful detection of immunoglobulins was achieved… CONTINUE READING

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