A white matter stroke model in the mouse: axonal damage, progenitor responses and MRI correlates.

@article{Sozmen2009AWM,
  title={A white matter stroke model in the mouse: axonal damage, progenitor responses and MRI correlates.},
  author={Elif G. Sozmen and Arunima Kolekar and Leif A Havton and S Thomas Carmichael},
  journal={Journal of neuroscience methods},
  year={2009},
  volume={180 2},
  pages={261-72}
}
Subcortical white matter stroke is a common stroke subtype but has had limited pre-clinical modeling. Recapitulating this disease process in mice has been impeded by the relative inaccessibility of the subcortical white matter arterial supply to induce white matter ischemia in isolation. In this report, we detail a subcortical white matter stroke model developed in the mouse and its characterization with a comprehensive set of MRI, immunohistochemical, neuronal tract tracing and electron… CONTINUE READING
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