A white matter lesion-filling approach to improve brain tissue volume measurements

  title={A white matter lesion-filling approach to improve brain tissue volume measurements},
  author={Sergi Valverde and Arnau Oliver and Xavier Llad{\'o}},
  booktitle={NeuroImage: Clinical},
Multiple sclerosis white matter (WM) lesions can affect brain tissue volume measurements of voxel-wise segmentation methods if these lesions are included in the segmentation process. Several authors have presented different techniques to improve brain tissue volume estimations by filling WM lesions before segmentation with intensities similar to those of WM. Here, we propose a new method to refill WM lesions, where contrary to similar approaches, lesion voxel intensities are replaced by random… CONTINUE READING
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