A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis

@article{MelndezHevia2009AWL,
  title={A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis},
  author={Enrique Mel{\'e}ndez-Hevia and Patricia de Paz-Lugo and Athel Cornish-Bowden and Mar{\'i}a Luz C{\'a}rdenas},
  journal={Journal of Biosciences},
  year={2009},
  volume={34},
  pages={853-872}
}
In a previous paper, we pointed out that the capability to synthesize glycine from serine is constrained by the stoichiometry of the glycine hydroxymethyltransferase reaction, which limits the amount of glycine produced to be no more than equimolar with the amount of C 1 units produced. [] Key Result Detailed assessment of all possible sources of glycine shows that synthesis from serine accounts for more than 85% of the total, and that the amount of glycine available from synthesis, about 3 g/day, together…
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