A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis

E. Meléndez-Hevia; Patricia Paz-Lugo; A. Cornish-Bowden; M. Cárdenas

DOI:10.1007/s12038-009-0100-9

Corpus ID: 2786988

A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis

@article{MelndezHevia2009AWL,
  title={A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis},
  author={E. Mel{\'e}ndez-Hevia and Patricia Paz-Lugo and A. Cornish-Bowden and M. C{\'a}rdenas},
  journal={Journal of Biosciences},
  year={2009},
  volume={34},
  pages={853-872}
}

E. Meléndez-Hevia, Patricia Paz-Lugo, +1 author M. Cárdenas

Published 2009

Medicine, Biology

Journal of Biosciences

In a previous paper, we pointed out that the capability to synthesize glycine from serine is constrained by the stoichiometry of the glycine hydroxymethyltransferase reaction, which limits the amount of glycine produced to be no more than equimolar with the amount of C 1 units produced. [...] Key Result Detailed assessment of all possible sources of glycine shows that synthesis from serine accounts for more than 85% of the total, and that the amount of glycine available from synthesis, about 3 g/day, together…Expand Abstract

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