A volunteer model for the comparison of laxatives in opioid-related constipation.

@article{Sykes1996AVM,
  title={A volunteer model for the comparison of laxatives in opioid-related constipation.},
  author={Nigel P Sykes},
  journal={Journal of pain and symptom management},
  year={1996},
  volume={11 6},
  pages={363-9}
}
  • Nigel P Sykes
  • Published 1996 in Journal of pain and symptom management
Loperamide was used to provide a source of opioid-induced constipation in healthy volunteers. Each volunteer took a sequence of three dose levels of loperamide. One of three laxatives was used to counterbalance the effect of loperamide and restore bowel function to what the individual considered normal at each stage before the dose of loperamide was increased. Lactulose, senna, and codanthrusate were selected as examples of a softening, a stimulant, and a combination laxative, respectively… CONTINUE READING