A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-Å resolution

@article{Fox1982AVI,
  title={A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-Å resolution},
  author={Robert O. Fox and Frederic M. Richards},
  journal={Nature},
  year={1982},
  volume={300},
  pages={325-330}
}
The crystal structure of alamethicin in nonaqueous solvent has been determined, and refined at 1.5-Å resolution. The molecular conformation of the three crystallographically independent molecules is largely α-helical with a bend in the helix axis at an internal proline residue. The helix structure is highly amphipathic as most of the solvent-accessible polar atoms lie on a narrow strip of surface parallel to the helix axis. Molecular models for the voltage-gated ion channel, with n-fold… 
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