• Corpus ID: 28176654

A voltage-dependent fluorescent indicator for optogenetic applications , archaerhodopsin-3 : Structure and optical properties from modeling in silico

  title={A voltage-dependent fluorescent indicator for optogenetic applications , archaerhodopsin-3 : Structure and optical properties from modeling in silico},
  author={Boitsov and Panov and Ryazantsev},
It was demonstrated in recent studies that some rhodopsins can be used in optogenetics as fluorescent indicators of membrane voltage. One of the promising candidates for these applications is archaerhodopsin-3. However, the fluorescent signal for wild-type achaerhodopsin-3 is not strong enough for real applications. Rational design of mutants with an improved signal is an important task, which requires both experimental and theoretical studies. Herein, we used a homology-based computational… 

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