A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.

@article{Bettoun2002AVD,
  title={A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.},
  author={David J Bettoun and Donald W. Buck and Jianfen Lu and Berket Khalifa and William Wei Lim Chin and Sunil Nagpal},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 28},
  pages={
          24847-50
        }
}
We provide evidence of a cross-talk between nuclear receptor and Ser/Thr protein phosphatases and show that vitamin D receptor (VDR) interacts with the catalytic subunit of protein phosphatases, PP1c and PP2Ac, and induces their enzymatic activity in a ligand-dependent manner. PP1c specifically interacts with VDR but not retinoic acid receptor alpha and retinoid X receptor alpha in yeast. Although VDR-PP1c and VDR-PP2Ac interaction is ligand-independent in vivo, 1alpha,25-dihydroxy-vitamin D(3… CONTINUE READING
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