A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis.

  title={A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis.},
  author={Kojiro Makibayashi and Mikiko Tatematsu and Michinori Hirata and Naoshi Fukushima and Kengo Kusano and Seiji Ohashi and Hideharu Abe and K Kuze and Atsushi Fukatsu and Takeshi Kita and Toshio Doi},
  journal={The American journal of pathology},
  volume={158 5},
OCT (22-oxa-calcitriol), a vitamin D analog, has been reported to show strong inhibitory effects on mesangial cell proliferation in vitro. In the present study, we report a study of the effect of OCT on anti-thy-1 glomerulonephritis. Both OCT and 1,25(OH)(2)D(3) significantly inhibited mesangial cell proliferation, the degree of glomerulosclerosis, and albuminuria at day 8 compared to the disease control group. The OCT-treated group showed normal calcium levels but the 1,25(OH)(2)D(3)-treated… CONTINUE READING