A viscous solvent enables information transfer from gene-length nucleic acids in a model prebiotic replication cycle.

@article{He2017AVS,
  title={A viscous solvent enables information transfer from gene-length nucleic acids in a model prebiotic replication cycle.},
  author={Christine Y. He and Isaac G{\'a}llego and Brandon Laughlin and Martha A. Grover and Nicholas V Hud},
  journal={Nature chemistry},
  year={2017},
  volume={9 4},
  pages={318-324}
}
Many hypotheses concerning the nature of early life assume that genetic information was once transferred through the template-directed synthesis of RNA, before the emergence of coded enzymes. However, attempts to demonstrate enzyme-free, template-directed synthesis of nucleic acids have been limited by 'strand inhibition', whereby transferring information from a template strand in the presence of its complementary strand is inhibited by the stability of the template duplex. Here, we use solvent… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Ester formation and hydrolysis during wet – dry cycles : generation of far - from - equilibrium polymers in a model prebiotic reaction

I. Mamajanov
Macromolecules • 2014

Interconversion between three overstretched DNA structures.

Journal of the American Chemical Society • 2014

a common goal of prebiotic chemistry and bottom-up synthetic biology

B. J. Cafferty, Hud, N. V. Abiotic synthesis of RNA in water
Curr. Opin. Chem. Biol. 22, 146–157 • 2014

generation of far-from-equilibrium polymers in a model prebiotic reaction

Mamajanov, I. et al. Ester formation, hydrolysis during wet–dry cycles
Macromolecules 47, 1334–1343 • 2014

Escalation of polymerization in a thermal gradient.

Proceedings of the National Academy of Sciences of the United States of America • 2013

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