A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge.

@article{Liu2012AVP,
  title={A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge.},
  author={Qingwei Liu and Kexia Yan and Yanfang Feng and Xulin Huang and Zhiqiang Ku and Yicun Cai and Fei Liu and Jinping Shi and Zhong Huang},
  journal={Vaccine},
  year={2012},
  volume={30 47},
  pages={
          6642-8
        }
}
Coxsackievirus A16 (CVA16) is one of the main causative agents of hand, foot and mouth disease (HFMD), which has been prevalent in the Asia-Pacific region over the last several years. However, no vaccine is yet available to prevent HFMD. Here we report the development of a virus-like particle (VLP) based experimental CVA16 vaccine. CVA16 VLPs were produced in insect cells by co-expression of the P1 and 3CD proteins of CVA16 using recombinant baculoviruses. Biochemical and biophysical analyses… CONTINUE READING
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