A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.

@article{Engel2008AVS,
  title={A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.},
  author={Stanislav Engel and Amanda P. Skoumbourdis and John M Childress and Susanne Neumann and Jeffrey R. Deschamps and Craig J. Thomas and A O Colson and Stefano Costanzi and Marvin C Gershengorn},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 15},
  pages={5115-23}
}
Virtual screening has become a major focus of bioactive small molecule lead identification, and reports of agonists and antagonists discovered via virtual methods are becoming more frequent. G protein-coupled receptors (GPCRs) are the one class of protein targets for which success with this approach has been limited. This is likely due to the paucity of detailed experimental information describing GPCR structure and the intrinsic function-associated structural flexibility of GPCRs which present… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

G Protein-Coupled Receptors - Modeling and Simulation

Advances in Experimental Medicine and Biology • 2014
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.

Perspect

R. S. Pearlman, K. M. Smith
Drug Disco V ery Des . • 1998

Similar Papers

Loading similar papers…