A virophage at the origin of large DNA transposons.

@article{Fischer2011AVA,
  title={A virophage at the origin of large DNA transposons.},
  author={Matthias Fischer and Curtis A Suttle},
  journal={Science},
  year={2011},
  volume={332 6026},
  pages={231-4}
}
DNA transposons are mobile genetic elements that have shaped the genomes of eukaryotes for millions of years, yet their origins remain obscure. We discovered a virophage that, on the basis of genetic homology, likely represents an evolutionary link between double-stranded DNA viruses and Maverick/Polinton eukaryotic DNA transposons. The Mavirus virophage parasitizes the giant Cafeteria roenbergensis virus and encodes 20 predicted proteins, including a retroviral integrase and a protein-primed… CONTINUE READING
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