A viral transcriptional activator of Kaposi's sarcoma-associated herpesvirus (KSHV) induces apoptosis, which is blocked in KSHV-infected cells.

@article{Nishimura2003AVT,
  title={A viral transcriptional activator of Kaposi's sarcoma-associated herpesvirus (KSHV) induces apoptosis, which is blocked in KSHV-infected cells.},
  author={Ken Nishimura and Keiji Ueda and Shuhei Sakakibara and Eunju Do and Eriko Ohsaki and Toshiomi Okuno and Koichi Yamanishi},
  journal={Virology},
  year={2003},
  volume={316 1},
  pages={64-74}
}
Replication and transcription activator (RTA), mostly encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50, is expressed in the immediate-early phase of reactivation and plays a critical role in inducing the viral lytic cycle in KSHV-infected cells. We established cell clones from BJAB cells and replication-deficient BCBL-1 cells in which KSHV RTA expression was controlled by an inducible promoter of the tetracycline-based Tet-Off expression system. In RTA-inducible… CONTINUE READING

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