A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.

@article{Coscoy2001AVP,
  title={A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.},
  author={Laurent Coscoy and Donald E Ganem},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 12},
  pages={1599-606}
}
Kaposi's sarcoma-associated (KS-associated) herpesvirus (KSHV) is a B-lymphotropic agent linked to AIDS-related lymphoproliferative disorders and KS. We and others have earlier identified two viral genes, K3 and K5, that encode endoplasmic reticulum proteins that downregulate surface MHC-I chains by enhancing their endocytosis. Here we have examined the ability of these proteins to influence the disposition of other host surface proteins implicated in immune recognition and activation. We… CONTINUE READING

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