A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2.

@article{Chen1985AVL,
  title={A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2.},
  author={Sai Chen and Nikki J. Holbrook and Kenneth F. Mitchell and Cayetano Vallone and Judith S. Greengard and Gerald R Crabtree and Y Lin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 21},
  pages={7284-8}
}
The gibbon leukemia cell line MLA 144 differs from every other T-lymphocyte line in that it constitutively makes interleukin 2 (IL-2) (also called T-cell growth factor) without stimulation by antigen, lectin, or tumor promoters. Previous work in which glucocorticoids were used to inhibit IL-2 production has indicated that proliferation of this cell line is dependent upon endogenously produced IL-2. We have found that the MLA 144 cell line has a copy of the gibbon leukemia virus inserted into… CONTINUE READING