A viral activator of gene expression functions via the ubiquitin-proteasome pathway.

@article{Everett1998AVA,
  title={A viral activator of gene expression functions via the ubiquitin-proteasome pathway.},
  author={Roger D. Everett and Anne Orr and Christopher M. Preston},
  journal={The EMBO journal},
  year={1998},
  volume={17 24},
  pages={7161-9}
}
The ability of herpes simplex virus type 1 (HSV-1) to attain a latent state in sensory neurones and reactivate periodically is crucial for its biological and clinical properties. The active transcription of the entire 152 kb viral genome during lytic replication contrasts with the latent state, which is characterized by the production of a single set of nuclear-retained transcripts. Reactivation of latent genomes to re-initiate the lytic cycle therefore involves a profound change in viral… CONTINUE READING

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