A vertebrate case study of the quality of assemblies derived from next-generation sequences

@inproceedings{Ye2010AVC,
  title={A vertebrate case study of the quality of assemblies derived from next-generation sequences},
  author={Liang Ye and LaDeana W. Hillier and Patrick Minx and Nay Thane and Devin Paul Locke and John C. Martin and Lei Chen and Makedonka Dautova Mitreva and Jason R. Miller and Kevin V Haub and D. James Dooling and Elaine R. Mardis and Richard K. Wilson and George Weinstock and Wesley C. Warren},
  booktitle={Genome Biology},
  year={2010}
}
The unparalleled efficiency of next-generation sequencing (NGS) has prompted widespread adoption, but significant problems remain in the use of NGS data for whole genome assembly. We explore the advantages and disadvantages of chicken genome assemblies generated using a variety of sequencing and assembly methodologies. NGS assemblies are equivalent in some ways to a Sanger-based assembly yet deficient in others. Nonetheless, these assemblies are sufficient for the identification of the majority… CONTINUE READING
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