A versatile ultra-high performance LC-MS method for lipid profiling☆

@inproceedings{Knittelfelder2014AVU,
  title={A versatile ultra-high performance LC-MS method for lipid profiling☆},
  author={Oskar L. Knittelfelder and Bernd P. Weberhofer and Thomas O Eichmann and Sepp D. Kohlwein and Gerald N Rechberger},
  booktitle={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2014}
}
A new UPLC-based untargeted lipidomic approach using a qTOF hybrid mass spectrometer is introduced. The applied binary gradient enables separations of lipid species including constitutional isomeric compounds and low abundant lipid classes such as phosphatidic acid (PA). Addition of phosphoric acid to the solvents improves peak shapes for acidic phospholipids. MS(E) scans allow simultaneous acquisition of full scan data and collision induced fragmentation to improve identification of lipid… CONTINUE READING

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