A versatile method for analysis of serine/threonine posttranslational modifications by β-elimination in the presence of pyrazolone analogues.

@article{Furukawa2011AVM,
  title={A versatile method for analysis of serine/threonine posttranslational modifications by β-elimination in the presence of pyrazolone analogues.},
  author={Jun-ichi Furukawa and Naoki Fujitani and Kayo Araki and Yasuhiro Takegawa and Kota Kodama and Yasuro Shinohara},
  journal={Analytical chemistry},
  year={2011},
  volume={83 23},
  pages={9060-7}
}
Post-translational modifications (PTMs) of serine and threonine occur by diverse mechanisms, including phosphorylation, sulfation, and various types of sugar chain modifications, making characterization of the resulting structures very labor-intensive. Moreover, to fully understand the biological functions of PTMs, both the sites of modification and the modified structures must be analyzed. The present work describes a novel, versatile strategy in which the released O-glycan and the formerly… CONTINUE READING
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