A versatile, non-biomimetic route to the preussomerins: syntheses of (+/-)-preussomerins F, K and L.

@article{Quesada2004AVN,
  title={A versatile, non-biomimetic route to the preussomerins: syntheses of (+/-)-preussomerins F, K and L.},
  author={Ernesto Quesada and Martin Stockley and Jacques P Ragot and Michael E Prime and Adrian C Whitwood and Richard J. Taylor},
  journal={Organic & biomolecular chemistry},
  year={2004},
  volume={2 17},
  pages={2483-95}
}
The first total syntheses of the title fungal metabolites preussomerins F, K and L are described and their structures confirmed thereby. The syntheses were achieved following a versatile, unified, non-biomimetic approach, which is easily extendable to prepare other known and novel members of this family. Key steps include the functionalisation of a 2-arylacetal anion, tandem one-pot Friedel-Crafts cyclisation-deprotection, regioselective substrate-directable hydrogenation and reductive-opening… CONTINUE READING

References

Publications referenced by this paper.

Progress in the Chemistry of Organic Natural Products; ed

  • K. Krohn
  • 2003

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