A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation.

@article{Clark1998AVE,
  title={A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation.},
  author={Dawn E. Clark and Stephen K. Smith and Ya Ping He and K. A. Day and Diana R Licence and Anthony N. Corps and R Lammoglia and D. Stephen Charnock-Jones},
  journal={Biology of reproduction},
  year={1998},
  volume={59 6},
  pages={1540-8}
}
Vascular endothelial growth factor (VEGF) is a potent secreted factor that promotes angiogenesis and maintains the integrity of the endothelium. Levels of VEGF are increased in many tumors and are elevated in women with pre-eclampsia, a serious disease of pregnancy. Here we show by in situ hybridization that the trophoblast contains the mRNA encoding a soluble version of the VEGF receptor known as Flt-1 (sFlt-1: initially described by Kendall and Thomas, PNAS 90:10705-10709). Binding assays and… CONTINUE READING

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