A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic ‘tail’ absent from purified glycoprotein

@article{Boothroyd1980AVS,
  title={A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic ‘tail’ absent from purified glycoprotein},
  author={John C Boothroyd and George A. M. Cross and Jan H. J. Hoeijmakers and Piet Borst},
  journal={Nature},
  year={1980},
  volume={288},
  pages={624-626}
}
Sequential expression of variant surface glycoproteins (VSGs) enables the parasitic protozoan Trypanosoma brucei to evade the immune response of its mammalian hosts1,2. Studies of several VSGs, which have been isolated as soluble molecules following disruption of cells in the absence of detergent, have indicated extensive amino acid diversity3–5 and the absence of a hydrophobic segment which might serve to anchor the carboxy terminus to the membrane5. The carboxy-terminal tryptic peptides of… CONTINUE READING

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