A variant form of myelodysplastic syndrome with Ph- minor-BCR/ABL transcript.

Abstract

This study concerns a patient with minor (m)-BCR/ABL transcript-positive and Philadelphia (Ph) chromosome-negative myelodysplastic syndrome (MDS). The patient was a 78-year-old man whose condition was diagnosed as refractory anemia with excess of blasts in transformation. Molecular genetic studies, using reverse transcriptase polymerase chain reaction analysis detected m-BCR/ABL messenger RNA. We used spectral karyotyping to analyze metaphase cells but could not detect a Ph chromosome. Fluorescence in situ hybridization, however, revealed fusion signals of BCR and ABL probes on an apparently normal chromosome 22.

Cite this paper

@article{Wakayama2001AVF, title={A variant form of myelodysplastic syndrome with Ph- minor-BCR/ABL transcript.}, author={Toshio Wakayama and Yasuhisa Maniwa and Hiroatsu Ago and Naoki Kakazu and Toshiaki Abe}, journal={International journal of hematology}, year={2001}, volume={74 1}, pages={58-63} }