A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro

@article{Bond1993AVE,
  title={A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro},
  author={Jane A Bond and Fiona S. Wyllie and Mircea Ivan and Timothy P Dawson and D Wynfordthomas},
  journal={Molecular and Cellular Endocrinology},
  year={1993},
  volume={93},
  pages={175-183}
}
We describe the existence in normal human primary thyroid cultures of a hitherto unrecognised sub-population of epithelial cells. This variant phenotype is characterised by squamoid morphology, absence of thyroglobulin, and an altered profile of intermediate filament expression. We suggest that these cells are derived from scattered foci of squamous metaplasia present in the normal gland. Although they are initially present at a frequency of less than 10(-4), their very high proliferative… CONTINUE READING

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