A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.

@article{Hungate2016AVA,
  title={A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.},
  author={Eric A. Hungate and Sapana R Vora and Eric R. Gamazon and Takaya Moriyama and Timothy Best and Imge Hulur and Younghee Lee and Tiffany-Jane Evans and Eva Ellinghaus and Martin Stanulla and J{\'e}r{\'e}mie Rudant and Laurent Orsi and Jacqueline Clavel and Elizabeth Milne and Rodney J. Scott and Ching-Hon Pui and Nancy J. Cox and Mignon L Loh and Jun J. Yang and Andrew D. Skol and Kenan Onel},
  journal={Nature communications},
  year={2016},
  volume={7},
  pages={10635}
}
Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and replicate a locus indexed by rs77728904 at 9p21.3 associated with BCP-ALL susceptibility (Pcombined=3.32 × 10(-15), OR=1.72) and independent from rs3731217, the previously reported ALL-associated variant in this region. Of correlated SNPs tagged by this… CONTINUE READING
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