A variant L.E. cell factor reactive only with "altered" nuclear material.

@article{Svec1963AVL,
  title={A variant L.E. cell factor reactive only with "altered" nuclear material.},
  author={Kathryn H. Svec and Melvin H. Kaplan},
  journal={Arthritis and rheumatism},
  year={1963},
  volume={6},
  pages={
          11-22
        }
}
An unusual antinuclear factor is described in a lupus erythematosus serum which shows L.E. cell activity. The serum was non-reactive with nuclei of intact cells and with thymus nucleoprotein but demonstrated reactivity with leukocyte nuclei altered by mechanical trauma. It is suggested that this antinuclear factor is related to the L.E. cell activity of the serum and represents a second type of L.E. cell factor. Es describite un inusual factor antinucleari trovate in un sero de lupus… 
15 Citations
On the incidence of antinuclear factors in rheumatoid arthritis. A comparative study, with special reference to the reaction with polymorphonuclear granulocytes.
  • P. Elling
  • Medicine, Biology
    Acta rheumatologica Scandinavica
  • 1967
TLDR
Sera investigated for the presence of antinuclear factors as determined by the immunofluorescent antibody technique indicate that the nuclear reactivity of sera in rheumatoid arthritis is mainly directed against the nuclei of the polymorphonuclear granulocytes.
Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of gamma-globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis.
The gammaG-globulin eluted at acid pH from kidney cortex homogenates and isolated glomeruli of five of six patients with lupus nephritis was found to exhibit antinuclear activity, which was not
STUDIES ON ANTINUCLEAR ANTIBODIES
TLDR
This paper presents the results of a systematic study of a large number of sera from patients with various diseases, including SLE and from healthy controls, which determined the incidence of circulating antibodies to desoxyribonucleic acid, deoxy ribonucleoprotein and of antinuclear factors detected by indirect immunofluorescence.
Granulocyte‐Specific Antinuclear Antibodies
TLDR
This chapter focuses on granulocyte-specific antinuclear antibodies (GS-ANA), which are mainly type G immunoglobulin antibodies with a tendency to engage in circulating and synovial fluid immune complexes in rheumatoid arthritis and Felty's syndrome.
HYPERSENSITIVITY TO DEOXYRIBONUCLEIC ACID IN CUTANEOUS DISEASE.
TLDR
Intraderma testing employing DNA is a moderately sensitive but poorly specific means for detecting apparent delayed (cellular) hypersensitivity to nucleoprotein and may have some merit in screening large population groups but lacks reliability since some patients with clinically active, untreated disease do not react.
III. Presence of LE factor in relatives and spouses
TLDR
The prevalence of LE factor was significantly increased in relatives compared with their spouses, female first degree relatives presenting the highest frequencies and the presence of LEFactor in relatives was correlated to presence of rheumatic disease, but LE factor also occurred in apparently healthy relatives.
...
1
2
...

References

SHOWING 1-10 OF 16 REFERENCES
A DNA-Reacting Factor in Serum of a Patient with Lupus Erythematosus Diffusus.∗
  • R. Ceppellini, E. Polli, F. Celada
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1957
TLDR
In serum of a patient with acute Lupus Erythematosus diffusus a factor has been found specifically reacting with purified DNA, and under usual criteria it seems to behave like an antibody.
The nucleoprotein complement-fixation test in the diagnosis of systemic lupus erythematosus.
TLDR
A gamma-globulin factor in the serum of patients with systemic lupus erythematosus that reacts with isolated cell nuclei or nucleoprotein 2 has been detected in many ways, and methods for the detection of antinuclear antibodies have proved useful both clinically and in immunologic investigations.
THE PRECIPITIN REACTION BETWEEN DNA AND A SERUM FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS
TLDR
The accumulated evidence, although not yet conclusive, favors the concept that the precipitating factor represents an antibody to DNA, and that it is one of a number of autoantibodies elicited in this disease.
On the interaction of dead leukocytic nuclei, L. E. factor and living leukocytes in the L. E. cell phenomenon.
TLDR
These studies suggest that the living leukocytes, apart from simple phagocytosis, serve other functions in the L.E. E. factor cells, including transformation into swollen homogenous lupus bodies.
Complement Fixation with Cell Nuclei and DNA in Lupus Erythematosus
TLDR
Sera from patients with active lupus erythematosus fixed complement with a wide variety of nuclei from different organs and species, with calf thymus nucleoprotein, and in two instances with histone, suggesting the presence of 2 distinct serum factors.
Passive cutaneous anaphylaxis reactions with a systemic lupus erythematosus serum factor and isolated DNA.
TLDR
The data presented provide additional evidence for the concept that the DNA-precipitating γ-globulin, present in a number of SLE sera, may be an antibody to DNA.
Antibodies to denatured desoxyribonucleic acid in a lupus erythematosus serum.
TLDR
Thermally denatured DNA was shown to be a more reactive antigen than native DNA, and DNase-digested antigen preparations failed to react but were effective inhibitors.
A Serum Factor in Lupus Erythematosus with Affinity for Tissue Nuclei
TLDR
For help in providing clinical material I am particularly indebted to Dr. Stewart Barber, who generously gave me access to his cases, and Dr. Jeffrey was a tower of strength at all stages, and in particular I am grateful for his advice on the clinical pathology.
Interaction of nuclei and globulin from lupus erythematosis serum demonstrated with fluorescent antibody.
Summary Using the fluorescent antibody technique a globulin component with a marked affinity for nuclei has been demonstrated in serum of patients with disseminated lupus erythematosis. It has been
Immunologic studies of heart tissue. IV. Serologic reactions with human heart tissue as revealed by immunofluorescent methods: isoimmune, Wassermann, and autoimmune reactions.
TLDR
Serologic reactions with homologous or autologous heart were observed particularly frequently with sera from rheumatic patients approximately 2 weeks following cardiac surgery, as well as in some non-rheumatic Patients following cardiac or thoracic surgery or acute myocardial infarction.
...
1
2
...