A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria

@article{Voss2006AVG,
  title={A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria},
  author={Till S Voss and Julie Healer and Allison J. Marty and Michael F Duffy and Jennifer K. Thompson and James G Beeson and John C Reeder and Brendan Crabb and Alan F Cowman},
  journal={Nature},
  year={2006},
  volume={439},
  pages={1004-1008}
}
Mono-allelic expression of gene families is used by many organisms to mediate phenotypic variation of surface proteins. In the apicomplexan parasite Plasmodium falciparum, responsible for the severe form of malaria in humans, this is exemplified by antigenic variation of the highly polymorphic P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1, encoded by the 60-member var gene family, represents a major virulence factor due to its central role in immune evasion and intravascular… CONTINUE READING
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