A validated spectrophotometric and liquid chromatography method for determination and purity evaluation of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine.

@article{Muszalska2003AVS,
  title={A validated spectrophotometric and liquid chromatography method for determination and purity evaluation of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine.},
  author={I. Muszalska and Helena Sadowska and D. Szkatuła},
  journal={Farmaco},
  year={2003},
  volume={58 7},
  pages={
          513-9
        }
}
A spectrophotometric analysis of the UV-spectrum of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (I) in 0.01 M HCl was performed by determining the values of specific absorption coefficients at the following analytical wavelengths: 224, 285 and 348 nm. The separation by means of TLC of compound I and of its five decomposition products was also studied. Silica gel coated plates (60 F(254)) were used and the mobile phase was… Expand
4 Citations
Kinetics of hydrolysis of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine in aqueous solutions.
TLDR
The pH-rate profile indicated specific acid- and base-catalyzed reactions as well as spontaneous water-catalysis of both dissociated and undissociated molecules of I and various buffer substances exhibited general acid and base catalysis of the degradation. Expand
Chromatographic Separation of Derivatives of 4‐Alkoxy‐6‐methyl‐1H‐pyrrolo[3,4‐c]pyridine‐1,3(2H)‐dione by TLC and HPLC
Abstract Five derivatives of 4‐alkoxy‐6‐methyl‐pyrrolo[3,4‐c]pyridine‐1,3‐dione were separated by TLC and HPLC methods using silica gel 60 F254 plates, analytical columns: LiChrosorb® RP‐8 (250×4 mm,Expand
Bioresearch of New 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones
TLDR
All of the new imides inhibited the locomotor activity in mice to a statistically significant extent, and two of them also prolonged the duration of thiopental sleep. Expand
Synthesis and thermal study of new N-substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)diones of Mannich base type
The new derivatives of 3,4-pyridinedicarboximide were synthesised. Experimental measurements were carried out using 1H NMR spectra, IR spectra, elemental analyses and differential scanningExpand

References

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TLDR
The compounds 8-12 exhibited potent analgesic activity which was superior than that of acetylsalicylic acid in two different tests and most of the investigated imides suppressed significantly spontaneous locomotor activity in mice. Expand
Investigations on the synthesis and properties of some N-[4-phenyl(2-pyrimidinyl)-1-piperazinyl]alkyl (hydroxyalkyl)-3,4-pyridinedicarboximides.
TLDR
Synthesis of 2-substituted N-2-hydroxy-3[4-phenyl(2-pyrimidinyl)-1-piperazinyl]propyl-6-methyl-3,4- pyridinedicarboximides [VI-XIV] is described, which displayed depressive action on the central nervous system. Expand
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The synthesis of N-aryl(heteroaryl)piperazinylalkyl derivatives of imide of 2-(1-piperidino)-3,4-pyridinedicarboxylic acid is reported. 3 examined compounds proved to be active pharmacologically inExpand
Synthesis, chemical and pharmacological properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides.
TLDR
Imide 11, containing 2-hydroxy-3-(4-phenyl-l-piperazinyl) propyl substituent at the nitrogen atom, proved to have the lowest toxicity and, at very high dosages, to be the most pharmacologically active. Expand