A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies.

@article{Plenis2007AVH,
  title={A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies.},
  author={A. Plenis and A. Chmielewska and L. Konieczna and H. Lamparczyk},
  journal={Biomedical chromatography : BMC},
  year={2007},
  volume={21 9},
  pages={
          958-66
        }
}
A rapid and sensitive reversed-phase high-performance liquid chromatographic method (RP-HPLC) with ultraviolet detection has been developed for the determination of moclobemide and its metabolites, p-chloro-N-(-2-morpholinoethyl)benzamide N'-oxide (Ro 12-5637) and p-chloro-N-[2-(3-oxomorpholino)ethyl]-benzamide (Ro 12-8095), in human plasma. The assay was performed after single liquid-liquid extraction with dichloromethane at alkaline pH using phenacetin as the internal standard… Expand
Classification of LC columns based on the QSRR method and selectivity toward moclobemide and its metabolites.
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Determination of moclobemide in human plasma by high-performance liquid chromatography with spectrophotometric detection.
LC determination of moclobemide and three metabolites in plasma.
Characterization of moclobemide N-oxidation in human liver microsomes
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