A validated assay for measuring doxorubicin in biological fluids and tissues in an isolated lung perfusion model: matrix effect and heparin interference strongly influence doxorubicin measurements.

@article{Kuemmerle2003AVA,
  title={A validated assay for measuring doxorubicin in biological fluids and tissues in an isolated lung perfusion model: matrix effect and heparin interference strongly influence doxorubicin measurements.},
  author={Andrea Kuemmerle and Thomas Krueger and Michael E. Dusmet and Corinne Vallet and Yinbin Pan and H. B. Ris and Laurent A Decosterd},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2003},
  volume={33 3},
  pages={475-94}
}
Doxorubicin is an antineoplasic agent active against sarcoma pulmonary metastasis, but its clinical use is hampered by its myelotoxicity and its cumulative cardiotoxicity, when administered systemically. This limitation may be circumvented using the isolated lung perfusion (ILP) approach, wherein a therapeutic agent is infused locoregionally after vascular isolation of the lung. The influence of the mode of infusion (anterograde (AG): through the pulmonary artery (PA); retrograde (RG): through… CONTINUE READING

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