A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study.

@article{Deng2013AVL,
  title={A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study.},
  author={Zhipeng Deng and Xin Wang and Huanxin Zhao and Shuxiang Cui and Qingqiang Yao and Hong Sook Bai},
  journal={Biomedical chromatography : BMC},
  year={2013},
  volume={27 6},
  pages={
          802-6
        }
}
Brazilin is a major homoisoflavonoid component isolated from the dried heartwood of traditional Chinese medicine Caesalpinia sappan L., which is a natural red pigment used for histological staining. Herein a sensitive, specific and rapid analytical LC-MS/MS method was established and validated for brazilin in rat plasma. After a simple step of protein precipitation using acetonitrile, plasma samples were analyzed using an LC-MS/MS system. Brazilin and the IS (protosappanin B) were separated on… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Determination of brazilin and protosappanin B in Caesalpinia sappan L. by HPLC.West China

  • HX Zhao, H Bai, YS Wang, Y Luan, YJ. Liu
  • Journal of Pharmaceutical Sciences
  • 2010
Highly Influential
9 Excerpts

Vibrational spectroscopic study of brazilin and brazilein, the main constituents of brazilwood from Brazil

  • L Oliveira, H Edwards, E Velozo, M. Nesbitt
  • Vibrational Spectroscopy
  • 2002
Highly Influential
9 Excerpts

Determination of brazilin and protosappanin B in Caesalpinia sappan L . by HPLC

  • HX Zhao, H Bai, YS Wang, Y Luan, YJ Liu
  • Lishizhen Medicine and Materia Medica Research
  • 2011

The effects on blood glucose, renal function and renal pathology of diabetic nephropathyrats by Sumu decoction

  • H Zhang, Z Zhang, XB Huang, H Li, YH Sun, XW. Huang
  • Lishizhen Medicine and Materia Medica Research
  • 2011
2 Excerpts

Research on the effect of Caesalpinia Sappan ethanol extract on the human lung cancer A549 cell

  • X Peng, LG Gu
  • Chinese Journal of Basic Medicine in Traditional…
  • 2009
1 Excerpt

Study on the proliferative inhibition and apoptosis of human gastric cancer cells with treatment of Caesalpinia sappan L

  • X Wang, SL Zhao, JG Xu, YF. Zhao
  • extract. Chinese Remedies and Clinics
  • 2007
2 Excerpts