A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees.

@article{Perales1995AVV,
  title={A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees.},
  author={M. Perales and D. Schwartz and J. Fabry and J. Lieberman},
  journal={Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association},
  year={1995},
  volume={10 1},
  pages={
          27-35
        }
}
  • M. Perales, D. Schwartz, +1 author J. Lieberman
  • Published 1995
  • Biology, Medicine
  • Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
Cytotoxic T lymphocytes (CTL) play an important role in the immune response to viral infection by recognizing and destroying infected cells. HIV-1 elicits an unusually strong CTL response in infected individuals and clearance of the viremia of acute infection coincides with the development of HIV-specific CTL. Because HIV-specific CTL may provide protection against de novo viral infection, we compared the CTL response in seronegative volunteers treated with two vaccination approaches. Seven… Expand

Paper Mentions

Interventional Clinical Trial
Evaluation of the safety and immunogenicity (immunological reactivity) of HIVAC-1e vaccine. An additional goal is to determine which dose level of vaccine might be most effective… Expand
ConditionsHIV Infections
InterventionBiological
Cellular HIV-1 immune responses in natural infection and after genetic immunization.
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