A vaccine combining two Leishmania braziliensis proteins offers heterologous protection against Leishmania infantum infection.


In the present study, two Leishmania braziliensis proteins, one hypothetical and the eukaryotic initiation factor 5a (EiF5a), were cloned and used as a polyproteins vaccine for the heterologous protection of BALB/c mice against infantum infection. Animals were immunized with the antigens separately or in association, and in both cases saponin was used as an… (More)
DOI: 10.1016/j.molimm.2016.06.014