A useful tool for the initial assessment of blood-brain barrier permeability after traumatic brain injury in rabbits: dynamic contrast-enhanced magnetic resonance imaging.

@article{Wei2011AUT,
  title={A useful tool for the initial assessment of blood-brain barrier permeability after traumatic brain injury in rabbits: dynamic contrast-enhanced magnetic resonance imaging.},
  author={Xiao-Er Wei and Dan Wang and Minghua Li and Yu-zhen Zhang and Yue-Hua Li and Wen-Bin Li},
  journal={The Journal of trauma},
  year={2011},
  volume={71 6},
  pages={1645-50; discussion 1650-1}
}
OBJECTIVE The aim of this study was to evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and its quantitative coefficient (K(trans)) in the assessment of the extent of traumatic brain injury (TBI) in a rabbit model. METHODS A weight-drop device (height, 20 cm) was used with varying impact force, 30-, 60-, or 90-g weight, to induce mild, moderate, or severe TBI, respectively. DCE-MRI and T2-weighted MRI was used to examine the injured groups and a sham group 1… CONTINUE READING
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