A useful testing strategy in phase III trials: combined test of superiority and test of equivalence.

@article{Morikawa1995AUT,
  title={A useful testing strategy in phase III trials: combined test of superiority and test of equivalence.},
  author={Tomotaka Morikawa and Masahiro Yoshida},
  journal={Journal of biopharmaceutical statistics},
  year={1995},
  volume={5 3},
  pages={297-306}
}
A useful testing strategy is proposed for a confirmatory phase III clinical trial. It consists of a combined test of superiority and test of equivalence, and it is easy to apply. By introducing the strategy, we can perform a post hoc analysis in a confirmatory experiment. Thus a more flexible decision will be possible than the usual single testing method provides. It is shown that the procedure needs no adjustment for multiplicity from the point of view of the closed testing procedure. The… CONTINUE READING

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