A use-dependent increase in release sites drives facilitation at calretinin-deficient cerebellar parallel-fiber synapses

@inproceedings{Brachtendorf2015AUI,
  title={A use-dependent increase in release sites drives facilitation at calretinin-deficient cerebellar parallel-fiber synapses},
  author={Simone Brachtendorf and Jens Eilers and Hartmut Schmidt},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
Endogenous Ca(2+)-binding proteins affect synaptic transmitter release and short-term plasticity (STP) by buffering presynaptic Ca(2+) signals. At parallel-fiber (PF)-to-Purkinje neuron (PN) synapses in the cerebellar cortex loss of calretinin (CR), the major buffer at PF terminals, results in increased presynaptic Ca(2+) transients and an almost doubling of the initial vesicular releases probability (p r). Surprisingly, however, it has been reported that loss of CR from PF synapses does not… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 52 references

Adaptation of granule cell to Purkinje cell synapses to high-frequency transmission.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 20 Excerpts
Highly Influenced

Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 11 Excerpts
Highly Influenced

Reliability and heterogeneity of calcium signaling at single presynaptic boutons of cerebellar granule cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2007
View 4 Excerpts
Highly Influenced

Calcium sensitivity of neurotransmitter release differs at phasic and tonic synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 18 Excerpts
Highly Influenced

Control of synaptic strength and timing by the release-site Ca2+ signal

J. H. Bollmann, B. Sakmann
Nat. Neurosci. 8, 426–434. doi: 10.1038/nn1417 • 2005
View 4 Excerpts
Highly Influenced

The influence of multivesicular release and postsynaptic receptor saturation on transmission at granule cell to Purkinje cell synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 9 Excerpts
Highly Influenced

Properties of unitary granule cell-->Purkinje cell synapses in adult rat cerebellar slices.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 5 Excerpts
Highly Influenced

Determinants of the time course of facilitation at the granule cell to Purkinje cell synapse.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1996
View 7 Excerpts
Highly Influenced

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